Human beings have an innate ability to repair. Stem cells play an important role in the tissue regeneration process.　”Stem cells” are a group of cells that have the ability to multiply infinitely on their own (self-renewal ability) and the ability to differentiate = transform into specific tissues (pluripotency).

By fully understanding and utilizing the abilities and characteristics of these cells, we can treat injuries and diseases by drawing out the self-renewal ability of biological tissues and restoring organ function. In the near future, it is expected that these stem cells will be used in a variety of ways.

Among stem cells, adipose tissue-derived stem cells, which are hidden in the subcutaneous tissue, which are easy to extract and have a large number, have recently attracted attention.

All regenerative medicine provided by Sobajima Clinic has passed the examination by the Specially Certified Regenerative Medicine Committee, and a notification regarding the “Regenerative Medicine Provision Plan” has been submitted to the Ministry of Health, Labour and Welfare and accepted.

❖ Anti-inflammatory effect　❖ Angiogenic effect　❖ Antifibrotic effect　❖ Ability to release growth hormones ❖ Ability to differentiate cells, etc ❖ Ability of homing

We offer various cell-based therapies including fresh stem cells treatments, cultured stem cells treatments, and a cell bank service.

■These new treatments are applicable to a range of diseases, including chronic orthopedic diseases such as osteoarthritis, rheumatoid arthritis (difficult to treat), and persistent neurological symptoms resulting from cervical and lumbar spine disorders that is designed to address conditions where traditional therapies have been insufficient.

■This treatment is pursued in cases where standard therapies have limited effectiveness, to avoid surgery, or to alleviate symptoms that persist after surgery.

■These treatments are believed to suppress inflammation and promote tissue repair, thereby preserving the body’s homeostasis as much as possible and delaying the degeneration of tissues

Human beings have an innate ability to repair. Stem cells play an important role in the tissue regeneration process. Among stem cells, adipose tissue-derived stem cells, which are hidden in the subcutaneous tissue, which are easy to extract and have a large number, have recently attracted attention. We provide treatment for many patients, including osteoarthritis, and the target diseases are expanding. Stem cells are currently used in a variety of diseases, pathophysiology, and preventive medicine, and are expected to be used in a variety of ways in the near future. However, while diseases and injuries at a young age are easily cured, diseases and injuries become harder to heal with age due to aging and a decrease in the number of stem cells.

The “Adipose Stem Cell Bank Service” provided by Medipreneur Co., Ltd., which is linked to Sobajima Clinic, collects healthy cells when they are young and healthy, freezes them, and makes them available when they are needed in the future (such as when they are sick or injured).

After giving a sufficient explanation and understanding, the subcutaneous fat (from the thighs, buttocks, etc.) of the person.Suction to be drawn. After that, the aspirated subcutaneous fat is collected by specialized staff at the “Cell Processing Center” set up in the facility, and stored for a long time in ultra-low temperature storage (minus 150 degrees Celsius or less). When treatment is necessary, it is thawed and administered to cells.

■Subcutaneous liposuction The patient’s own subcutaneous fat (usually buttocks and thighs) is sucked in a short time. A small amount of fat (about 10~20g) is sucked. Anesthesia is basically local anesthesia, and fat is collected safely and efficiently.

■Stem cell isolation Isolate adipose stem cells from the aspirated fat. Stem cells are separated while sterilization operations are performed, and concentrated stem cells are purified.

■Adipose Stem Cell Preservation The cells obtained by culturing are divided into several cells and stored. By dividing it into severaldoses, it will be possible to use your own adipose stem cells for various treatments in multiple doses in the future and receive regenerative medicine. (* A separate fee will be charged at the time of culture.) ）

https://pubmed.ncbi.nlm.nih.gov/?term=Sobajima+S

The influence of adipose-derived stromal vascular fraction cells on the treatment of knee osteoarthritis.

Tsubosaka M, Matsumoto T, Sobajima S, Matsushita T, Iwaguro H, Kuroda R.BMC Musculoskelet Disord. 2020 Apr 6;21(1):207. doi: 10.1186/s12891-020-03231-3.PMID: 32252731

Clinical use of autologous adipose-derived stromal vascular fraction cell injections for hip osteoarthritis.

Onoi Y, Matsumoto T, Sobajima S, Tsubosaka M, Hayashi S, Matsushita T, Iwaguro H, Kuroda R.Regen Ther. 2023 Jun 15;24:94-102. doi: 10.1016/j.reth.2023.06.006. eCollection 2023 Dec.PMID: 37363753

Comparison of Clinical and Imaging Outcomes of Different Doses of Adipose-Derived Stromal Vascular Fraction Cell Treatment for Knee Osteoarthritis.

Tsubosaka M, Matsumoto T, Sobajima S, Matsushita T, Iwaguro H, Kuroda R.Cell Transplant. 2021 Jan-Dec;30:9636897211067454. doi: 10.1177/09636897211067454.PMID: 35392685

Adipose tissue-derived regenerative cells improve implantation of fertilized eggs in thin endometrium.

Yotsumoto F, Iwaguro H, Harada Y, Sobajima S, Suwabe T, Miyamoto S.Regen Med. 2020 Jul;15(7):1891-1904. doi: 10.2217/rme-2020-0037. Epub 2020 Jul 23.PMID: 32698666

Paracrine effect of the stromal vascular fraction containing M2 macrophages on human chondrocytes through the Smad2/3 signaling pathway.

Fujita M, Matsumoto T, Hayashi S, Hashimoto S, Nakano N, Maeda T, Kuroda Y, Takashima Y, Kikuchi K, Anjiki K, Ikuta K, Onoi Y, Tachibana S, Matsushita T, Iwaguro H, Sobajima S, Hiranaka T, Kuroda R.J Cell Physiol. 2022 Sep;237(9):3627-3639. doi: 10.1002/jcp.30823. Epub 2022 Jun 29.PMID: 35766589

Efficacy and Safety of Tramadol Hydrochloride Twice-Daily Sustained-Release Bilayer Tablets with an Immediate-Release Component for Chronic Pain Associated with Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled, Treatment-Withdrawal Study.

Kawai S, Sobajima S, Jinnouchi M, Nakano H, Ohtani H, Sakata M, Adachi T.Clin Drug Investig. 2022 May;42(5):403-416. doi: 10.1007/s40261-022-01139-5. Epub 2022 Apr 18.PMID: 35435639 Clinical Trial.

Attenuation of Knee Osteoarthritis Progression in Mice through Polarization of M2 Macrophages by Intra-Articular Transplantation of Non-Cultured Human Adipose-Derived Regenerative Cells.

Kamada K, Matsushita T, Yamashita T, Matsumoto T, Iwaguro H, Sobajima S, Kuroda R.J Clin Med. 2021 Sep 22;10(19):4309. doi: 10.3390/jcm10194309.PMID: 34640324

Clinical and Radiological Comparison of Single and Double Intra-articular Injection of Adipose-Derived Stromal Vascular Fraction for Knee Osteoarthritis.

Fujita M, Matsumoto T, Sobajima S, Tsubosaka M, Matsushita T, Iwaguro H, Kuroda R.Cell Transplant. 2023 Jan-Dec;32:9636897231190175. doi: 10.1177/09636897231190175.PMID: 37551027 Clinical Trial.